Which of the following statement is correct?

(1) Catalytic activity is lost when the co-factor is removed from the enzyme.

(2) Coenzyme nicotinamide adenine dinucleotide (NAD) and NADP contains the vitamin niacin.

(3) Biomacromolecules have a hierarchy of structures such as primary, secondary, tertiary and quaternary.

(4) Enzymes lower the activation energy of reactions and enhance greatly the rate of the reactions.

(5) Nucleic acids carry hereditary information and are passed on from parental generation to progeny.